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A single or several drug overdose with oxycodone and acetaminophen is actually a potentially lethal polydrug overdose, and consultation which has a regional poison Handle Centre is usually recommended.In this case, blended agonist/antagonist analgesics might reduce the analgesic influence of oxycodone and/or might precipitate withdrawal indicators

Lamotrigine: Serum lamotrigine concentrations may be decreased, making a minimize in therapeutic consequences.Acetaminophen is metabolized within the liver by using cytochrome P450 microsomal enzyme. About 8085% from the acetaminophen in your body is conjugated principally with glucuronic acid and to a lesser extent with sulfuric acid and cysteine.